GMQ hydrochloride
CAS No. 5361-15-9
GMQ hydrochloride ( NSC 403387 hydrochloride )
Catalog No. M22257 CAS No. 5361-15-9
GMQ hydrochloride is a potent and selective acid-sensing ion channel (ASIC) modulator.?
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
10MG | 37 | In Stock |
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25MG | 55 | In Stock |
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50MG | 74 | In Stock |
|
100MG | 127 | In Stock |
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200MG | Get Quote | In Stock |
|
500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameGMQ hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionGMQ hydrochloride is a potent and selective acid-sensing ion channel (ASIC) modulator.?
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DescriptionGMQ hydrochloride is a potent and selective acid-sensing ion channel (ASIC) modulator.?It activates ASIC3 channels under neutral pH and blocks acid-induced maximal peak current.Addition of GMQ to pituitary GH3 cells raised the amplitude of Ca2+-activated K+ currents (IK(Ca)), which was reversed by verruculogen or PF1022A, but not by TRAM-39.?Under inside-out current recordings, addition of GMQ into bath enhanced the probability of large-conductance Ca2+-activated K+ (BKCa) channels with an EC50 value of 0.95 M. The activation curve of BKCa channels during exposure to GMQ shifted to a lower depolarized potential, with no change in the gating charge of the curve;?however, there was a reduction of free energy for channel activation in its presence.?As cells were exposed to GMQ, the amplitude of ion currents were suppressed, including delayed rectifying K+ current, voltage-gated Na+ and L-type Ca2+ currents.?In Rolf B1.T olfactory sensory neuron, addition of GMQ was able to induce inward current and to suppress peak INa.?
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SynonymsNSC 403387 hydrochloride
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PathwayOthers
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TargetOther Targets
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Recptorion channel (ASIC)
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Research Area——
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Indication——
Chemical Information
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CAS Number5361-15-9
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Formula Weight237.69
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Molecular FormulaC10H12ClN5
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1=NC(NC(N)=N)=NC2=C1C=CC=C2.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.So, Edmund, Cheung,et al. Multiple regulatory actions of 2-guanidine-4-methylquinazoline (GMQ), an agonist of acid-sensing ion channel type 3, on ionic currents in pituitary GH(3) cells and in olfactory sensory (Rolf B1.T) neurons[J]. Biochemical Pharmacology, 2018.
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